Survival of Patients with Trisomy 18 Based on the Treatment Policy at a Single Center in Korea
Neonatal Medicine
; : 251-258, 2014.
Artículo
en Coreano
| WPRIM (Pacífico Occidental)
| ID: wpr-53910
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
Although discussion about active treatment of trisomy 18 is increasing, there are no previous articles regarding this subject in Korea. In order to provide objective data about the clinical characteristics and survival of patients with trisomy 18, based on the treatment policy, to medical teams and parents with trisomy 18, we reviewed the medical records of such patients at a single center in Korea.METHODS:
This is a retrospective study of 22 patients diagnosed with trisomy 18 at the Samsung Medical Center between 1995 and 2013. We collected data about the clinical characteristics, including demographics, birth history, diagnosis method, and associated anomalies. We analyzed the survival in days, according to three broad categories of treatment policy give-up, conservative management and active treatment.RESULTS:
Of the 22 patients with confirmed trisomy 18, the majority were female (19, 86%). The median gestational age was 39 weeks (range, 31-41 weeks) and the median birth weight is 2,029 g (range, 1,130-2,990 g). Among the anomalies associated with trisomy 18, ventricular septal defect (86%) and patent ductus arteriosus (81%) were the most common cardiac anomalies; giant cisterna magna (59%) was the most common central nervous system anomaly; and clenched hands (73%) and low set ears (59%) were the most common structural anomalies. The survival based on the treatment policy was the highest in the active treatment group, followed by the conservative management group. The give-up group had the lowest survival.CONCLUSION:
It is possible to achieve an improvement in both survival and symptom relief for patients with trisomy 18, despite poor neurological outcome and high mortality. Medical personnel need to provide objective data on trisomy 18 to the parents, and determine the treatment policy through careful discussion.
Texto completo:
Disponible
Contexto en salud:
ODS3 - Salud y Bienestar
/
ODS3 - Meta 3.4 Reducir las muertes prematuras por enfermedades no transmisibles
Problema de salud:
Meta 3.8: Alcanzar cobertura universal de salud
/
Enfermedad Cardiovascular
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Anomalías Congénitas y Cromosómicas
/
Otras Enfermedades Circulatorias
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Padres
/
Trisomía
/
Peso al Nacer
/
Sistema Nervioso Central
/
Demografía
/
Registros Médicos
/
Estudios Retrospectivos
/
Mortalidad
/
Edad Gestacional
/
Cisterna Magna
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Aspecto:
Determinantes sociales de la salud
Límite:
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Neonatal Medicine
Año:
2014
Tipo del documento:
Artículo