Preparation and stability research of all-trans-retinoic acid liposomes / 第三军医大学学报

ABSTRACT

Objective To prepare and optimize formulation of ATRA liposomes. Methods ATRA liposomes was prepared by reverse evaporating method and to determine the concentration and the entrapment efficiency of ATRA liposomes by HPLC. Results The entrapment efficiency of the three ATRA liposomes formulations reached 33.98%, 42.11%, 70.34% respectively. The liposome was stable. The ATRA content of three formulations almost showed no change during the observing days. Conclusion The technique of preparing the ATRA liposomes is feasible and the method of quality control is simple and accurate.