Effect of rapamycin(RPM)on interleukin-10 gene expression in rats with postburn Staphylococcus aureus sepsis / 中华急诊医学杂志
Chinese Journal of Emergency Medicine
; (12)2006.
Article
en Zh
| WPRIM
| ID: wpr-574536
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the effect of rapamycin(RPM)on hepatic interleukin-10(IL-10)gene and acute liver injury in rats with postburn Staphylococcus aureus sepsis.Methods Fifty male Wistar rats were randomly divided into four groups:normal control group,scald control group,postburn sepsis group,and RPM treatment group.Tissue samples from liver and plasma were collected to determine IL-10 mRNA and protein expressions,and liver function parameters were also measured.Results Compared to postburn Staphylococcus aureus sepsis group,in RPM treatment group hepatic IL-10 mRNA expression and plasma IL-10 were significantly increased at 0.5 hour after RPM treatment(P
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Emergency Medicine
Año:
2006
Tipo del documento:
Article