Role of imprinted gene Insulin-like growth factor 2 in fetal growth / 医学研究生学报
Journal of Medical Postgraduates
; (12)2003.
Article
en Zh
| WPRIM
| ID: wpr-584865
Biblioteca responsable:
WPRO
ABSTRACT
Genomic imprinting plays a fundamental role in mammal fetal growth and behavior. Abnormal expression of imprinted genes is associated with some genetic diseases and cancers. Imprinted insulin-like growth factor 2 (IGF-2) controls fetal growth by regulating nutrient transportation in placenta. Paternal uniparental disomy, duplication of paternal allele and loss of imprinting are 3 molecular mechanisms of IGF-2 overexpression that can cause Beckwith-Weidemann’s syndrome (BWS). Some assisted reproductive techniques may cause some epigenetic changes that affect embryonic and postnatal development.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Medical Postgraduates
Año:
2003
Tipo del documento:
Article