A Multicenter Prospective Study of the Effect of Imipramine and Desmopressin on Arousability in Children with Nocturnal Enuresis / 대한비뇨기과학회지
Korean Journal of Urology
; : 168-173, 2008.
Artículo
en Coreano
| WPRIM (Pacífico Occidental)
| ID: wpr-63090
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
We performed a multicenter, prospective study to evaluate the efficacy of imipramine and desmopressin to improve arousability and prevent nocturnal enuresis(NE). MATERIALS ANDMETHODS:
The total of 48 children with NE were given questionnaires that included a scoring system for the assessing arousal from sleep. They were assigned into two groups group 1(imipramine 25 mg, 3 girls and 16 boys, mean age 7.9 years), group 2(desmopressin 0.2 mg, 9 girls and 9 boys, mean age 7.5 years). The assessment of arousability was repeated 2 weeks and 4 weeks after medication. Eleven children were excluded because of incomplete data.RESULTS:
Mean wetting events in group 1 decreased from 8.8 to 5.1 times(2 weeks) and 3.0 times(4 weeks)(p=0.009) versus 10.2 to 5.5 times(2 weeks) and 6.4 times(4 weeks)(p=0.007) for group 2. The mean threshold of arousability in group 1 was 4.9(baseline), 4.4(2 weeks), and 3.7(4 weeks), and, for group 2, 5.1(baseline), 4.8(2 weeks), and 4.8(4 weeks). The two groups were not different(p=0.14, p=0.73).CONCLUSIONS:
Imipramine and desmopressin, which are commonly used in treating NE in Korea, influenced wetting events but not arousability.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Nivel de Alerta
/
Estudios Prospectivos
/
Desamino Arginina Vasopresina
/
Enuresis Nocturna
/
Imipramina
/
Corea (Geográfico)
Tipo de estudio:
Ensayo clínico controlado
/
Estudio observacional
Límite:
Niño
/
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Korean Journal of Urology
Año:
2008
Tipo del documento:
Artículo