Development of an attenuated vaccine strain from a korean respiratory type infectious bronchitis virus / 대한수의학회지
Korean Journal of Veterinary Research
; : 193-201, 2011.
Artículo
en Coreano
| WPRIM (Pacífico Occidental)
| ID: wpr-65844
Biblioteca responsable:
WPRO
ABSTRACT
An attenuated vaccine strain AVR1/08 of Korean respiratory type of infectious bronchitis virus (IBV) was developed by 89th passages of IBV D85/06 strain in chicken eggs. The AVR1/08 strain had higher virus titer at least 20 times (10(1.3)) than the parent virus D85/06 by egg inoculation method. The AVR1/08 strain had a single point mutation (S to Y) at position 56 of spike protein of IBV compared to parent virus IBV D85/06 strain. The mutation was observed consistently at viruses after 47th passage in chicken eggs. The AVR1/08 strain showed no virulence even after 6 passages in chickens and all chickens inoculated induced anti-IBV antibody 14 days after vaccination. The AVR1/08 strain had broad protective efficacy against QX type Korean nephropathogenic virus (Q43/06 strain), KM91 type Korean nephropathogenic virus (KM91 strain) and Korean respiratory virus (D85/06 strain). In contrast, Massachusetts (Mass) type attenuated vaccine strain H120 showed protection of 37.5 to 50% against these three viruses. Our results indicate that the AVR1/08 strain has potential as an attenuated vaccine effective in controlling IBVs circulating in Korea.
Texto completo:
Disponible
Contexto en salud:
Agenda de Salud Sostenible para las Américas
/
ODS3 - Salud y Bienestar
Problema de salud:
Objetivo 10: Enfermedades transmisibles
/
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Óvulo
/
Padres
/
Esguinces y Distensiones
/
Virus
/
Pollos
/
Massachusetts
/
Vacunación
/
Mutación Puntual
/
Virus de la Bronquitis Infecciosa
/
Carga Viral
Límite:
Humanos
País/Región como asunto:
America del Norte
/
Asia
Idioma:
Coreano
Revista:
Korean Journal of Veterinary Research
Año:
2011
Tipo del documento:
Artículo