Effect of the dose-dense temozolomide on glioblastoma:A network meta-analysis / 实用医学杂志
The Journal of Practical Medicine
; (24): 3990-3994, 2017.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-665465
Biblioteca responsable:
WPRO
ABSTRACT
Objective To analyze the intervention effect of the dose-dense schemes of temozolomide on the newly diagnosed glioblastoma compared with the standard schemes. Methods The Pubmed,Cochrane,Em-base,CNKI,CBM,Wanfang,VIP databases were used for the retrievals on the intervention effect.The quality of included papers was assessed to extract network meta-analysis data with using the statistical software Stata 13.0. Results The treatment plans were ranked according to the intervention effect from the best to the worst as followsthe dose-dense,the early,the metronomic,the standard,the RT and post-RT adjuvant temozolomide. The most common adverse effects in hematotoxicity were neutropenia,leucopenia,lymphopenia,thrombocytopenia and ane-mia. Between the different temozolomide therapeutic regimens,there was no significant difference. Conclusion The intervention effect of the dose-dense schemes with temozolomide is better than the standard therapy. It also revealed that,the hematoxicity in the different temozolomide schemes is not significantly different.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Revisión sistemática
Idioma:
Chino
Revista:
The Journal of Practical Medicine
Año:
2017
Tipo del documento:
Artículo