Expression and significance of IGF-1 and GFAP in serum of glioma patients / 国际检验医学杂志

ABSTRACT

Objective To explore the expression and significance of insulin grow th factor 1(IGF-1) and gli-al fibriuary acidic protein(GFAP) in patients with glioma .Methods The serum levels of IGF-1 and GFAP in 40 glioma patients ,30 healthy subjects and 35 patients with other benign intracranial tumors were measured by double antibody sandwich method .Results There was no significant difference in serum IGF-1 and GFAP lev-els between healthy subjects and other benign intracranial tumor patients (P>0 .05) ,and the levels of IGF-1 and GFAP in the serum of glioma patients were significantly higher than those of healthy and other benign in-tracranial tumor patients (P<0 .05) .The serum levels of IGF-1 and GFAP in glioma patients after operation were significantly lower than those before operation (P< 0 .05) .Conclusion The expression of IGF-1 and GFAP in the serum of glioma patients is significantly higher than those of healthy subjects and other benign intracranial tumor patients .It has good sensitivity and specificity .It can be used as a serum marker of glioma patients and has certain clinical value .