Roles of interleukin-6 in occurrence, development and prognosis of hepatocellular carcinoma / 国际肿瘤学杂志

ABSTRACT

Interleukin-6 (IL-6) involves in a variety of inflammatory responses and immune regulation,showing closely correlations to tumor progression.Recent studies reveal that IL-6 may play an important role in constituting tumor microenvironment,activating related signal pathway,regulating downstream transcription factors,to affect the proliferation,invasion and metastasis of tumor cells.IL-6 has important potential value in the targeted therapy for hepatocellular carcinoma.