NMDA receptor and its role in cardiovascular diseases / 中南大学学报(医学版)

ABSTRACT

Cardiovascular disease is the main threat to human health,which is one of the important causes of death in worldwide.N-methyl-D-aspartate receptor (NMDAR) is one of crucial ionic glutamate receptors.The physiology and pharmacology function of the composition of NMDAR are very complicated.Researches have shown that NMDAR with a high permeability to calcium and a unique feature of controlling numerous calcium-dependent processes.NMDAR affects the occurrence and development of cardiovascular disease such as hypertension,arrhythmia,myocardial infarction.