Latest progress of the tumor suppressor gene and oncogene / 基础医学与临床

ABSTRACT

Under normal circumstances, tumor suppressor gene monitors cellular proliferation signals and prevents abnormal cell proliferation through inhibiting cell cycle progress, promoting cell senescence or apoptosis, thus a-chieves the function of cancer inhibition. On the contrary, the function of oncogene is to facilitate cell to escape from cell cycle control and promote the cell proliferation. Oncogenes may also inhibit cell apoptosis and results in uncontrollable cell growth. However, tumor suppressor gene may be converted to oncogene in different cellular con-text and gene mutation status, and vice versa.