Association between body mass index and outcome in lacunar infarction patients / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the association between body mass index (BMI) and outcome in lacunar infarction (LA) patients.Methods A total of 3410 LA patients were divided into BMI＜18.5 kg/m2 group(n=182),BMI=18.5-23.9 kg/m2 group (n=1639),BMI=24.0-27.9 kg/m2 group (n=1212) and BMI≥28.0 kg/m2 group (n=377) according to the TOAST typing in China Quality Evaluation of Stroke Care and Treatment Database.The end events included allcause mortality,death or severe disability,infection complications,and recurrent ischemic stroke at 12 months after onset of LA.Results The total all-cause mortality was significantly higher in BMI＜18.5 kg/m2 group than in BMI=18.5-23.9 kg/m2 group (19.1％ vs 6.7％,P＜0.01).No significant difference was found in total all-cause mortality between BMI =24.0-27.9 kg/m2 group and BMI≥28.0 kg/m2 group (6.0％ and 3.8％ vs 6.7％,P＞0.05).Multivariate logistic regression analysis showed that the risk of all-cause mortality,death or severe disability,infection complications,and recurrent ischemic stroke was higher in BMI＜18.5 kg/m2 group than in BMI=18.5 -23.9 kg/m2 group (HR=1.91,95％CI:1.22-2.98,OR=1.50,95％CI:1.05-2.14,OR=1.92,95 ％ CI:1.21-3.06,P＜0.05,P＜0.01).No significant difference was found in risk of recurrent ischemic stroke and end events between BMI＜18.5 kg/m2 group and BMI=18.5-23.9kg/m2 group.Conclusion The risk of poor outcome is higher while that of recurrent ischemic stroke remains unchanged in LA patients with their BMI＜18.5 kg/m2.