The analysis on tolerance and prognosis of chemotherapy in patients aged 80 year and over with lung cancer / 中华老年医学杂志

ABSTRACT

Objective To observe the tolerance and prognosis of chemotherapy in patients aged 80 year and over with lung cancer in China.Methods This retrospective study was performed on 30 patients aged 80 year and over with lung cancer who received chemotherapy at our hospital from 2012 to 2017.We collected basal clinical and laboratory data before chemotherapy,recorded the treatment regimens,side effects,and outcome of chemotherapy,and analyzed the overall survival of patients with stage Ⅳ lung cancer.Results The patients aged 80 90 years were mainly males (63.3％,19/30),and most of them had good performance status (PS) with PS 0-1 in 22 patients (73.3％) and activity of daily living (ADL) score ≥90 in 18 patients (60.0％).Patients were treated with a median of 4 chemotherapy courses,and half of them had adverse reactions of degree ⅢI or above.A total of 21 patients (70.0 ％) had myelosuppression and 3 (10.0 ％) had weakness,while clinical efficacy occurred in 17 (68.0％) patients.The median of overall survival was 8.5 months (95％CI:2.396-14.604) in 25 patients with stage IⅣ lung cancer.Conclusions Some patients with lung cancer aged 80 years and over can benefit from chemotherapy.The patients with better PS and ADL may be more suitable for chemotherapy.The adverse reactions of chemotherapy need to be closely monitored.