The incidence of venous thromboembolism is not lowin Korean patients with advanced pancreatic cancer
Blood Research
; : 227-232, 2018.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-716608
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND:
Pancreatic cancer is among the most common malignancies associated with venous thromboembolism (VTE). Asian patients are known to have a lower incidence of VTE compared to Caucasian patients. However, few studies have investigated the incidence of VTE in Asian patients with pancreatic cancer.METHODS:
This retrospective review of medical records was performed on 505 patients with histopathologically proven advanced stage pancreatic cancer, from January 2006 to December 2012, at Soonchunhyang University Hospitals.RESULTS:
Ninety-four patients (18.6%) had at least one pulmonary embolism (PE), deep vein thrombosis (DVT), or splanchnic vein thrombosis (SVT); 38 patients had isolated SVT; and 56 patients (11.1%) had at least one classic VTE (PE and/or DVT of lower extremities). Patients with more advanced stages of pancreatic cancer (distant metastatic stage, recurrence) or who had received chemotherapy had a higher incidence of classic VTE. Patients who were simultaneously diagnosed with pancreatic cancer and classic VTE had a poorer prognosis than patients with subsequent VTEs. There was a significant difference in overall survival (OS) between the presence and absence of a concurrent classic VTE diagnosis (median OS, 2.1 mo vs. 10.7 mo; P < 0.001). Even when VTE included SVT, the result was similar (P < 0.001).CONCLUSION:
In Korean patients with advanced pancreatic cancer, the incidence of VTEs is comparable to that of Caucasian patients. We also found that pancreatic cancer patients with concurrent VTEs had a poor prognosis compared to patients who developed VTEs later.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Pancreáticas
/
Pronóstico
/
Embolia Pulmonar
/
Trombosis
/
Venas
/
Registros Médicos
/
Incidencia
/
Estudios Retrospectivos
/
Trombosis de la Vena
/
Pueblo Asiatico
Tipo de estudio:
Estudio diagnóstico
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Blood Research
Año:
2018
Tipo del documento:
Artículo