Qualitative Comparison of Semantic Memory Impairment in Patients with Amnestic Mild Cognitive Impairment Based on β-Amyloid Status
Journal of Clinical Neurology
; : 27-37, 2019.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-719302
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE:
Semantic memory remains more stable than episodic memory across the lifespan, which makes it potentially useful as a marker for distinguishing pathological aging from normal senescence. To obtain a better understanding of the transitional stage evolving into Alzheimer's dementia (AD), we focused on the amnestic mild cognitive impairment (aMCI) stage stratified based on β-amyloid (Aβ) pathology.METHODS:
We analyzed the raw data from Korean version of the Boston Naming Test (K-BNT) and the Controlled Oral Word Association Test (COWAT). For K-BNT, the frequencies of six error types and accuracy rates were evaluated. For a qualitative assessment of the COWAT, we computed the number of switching, number of clusters, and mean cluster size.RESULTS:
The data from 217 participants were analyzed (53 normal controls, 66 with Aβ− aMCI, 56 with Aβ+ aMCI, and 42 disease controls). There were fewer semantically related errors and more semantically unrelated errors on the K-BNT in Aβ+ aMCI than in Aβ− aMCI, without a gross difference in the z score. We also found that Aβ+ aMCI showed a more prominent deficit in the number of clusters in the semantic fluency task [especially for animal names (living items)] than Aβ− aMCI.CONCLUSIONS:
In spite of similar clinical manifestations, Aβ+ aMCI was more similar to AD than Aβ− aMCI in terms of semantic memory disruption. Semantic memory may serve as an early indicator of brain Aβ pathology. Therefore, semantic memory dysfunction deserves more consideration in clinical practice. Longitudinal research with the follow-up data is needed.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Semántica
/
Pruebas de Asociación de Palabras
/
Encéfalo
/
Envejecimiento
/
Estudios de Seguimiento
/
Demencia
/
Enfermedad de Alzheimer
/
Memoria Episódica
/
Disfunción Cognitiva
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Investigación cualitativa
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Journal of Clinical Neurology
Año:
2019
Tipo del documento:
Artículo