Randomized Phase III Trial of Irinotecan Plus Cisplatin versus Etoposide Plus Cisplatin in Chemotherapy-Naïve Korean Patients with Extensive-Disease Small Cell Lung Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 119-127, 2019.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-719712
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
This randomized phase III study was designed to compare the efficacy and safety of irinotecan plus cisplatin (IP) over etoposide plus cisplatin (EP) in Korean patients with extensive-disease small-cell lung cancer (SCLC). MATERIALS ANDMETHODS:
Patients were randomly assigned to receive IP, composed of irinotecan 65 mg/m2 intravenously on days 1 and 8+cisplatin 70 mg/m2 intravenously on day 1 every 3 weeks, or EP, composed of etoposide 100 mg/m2 intravenously on days 1, 2, 3+cisplatin 70 mg/m2 intravenously on day 1, every 3 weeks for a maximum of six cycles, until disease progression, or until unacceptable toxicity occurred. The primary endpoint was overall survival.RESULTS:
A total of 362 patients were randomized to IP (n=173) and EP (n=189) arms. There were no significant differences between IP and EP arms for the median overall survival (10.9 months vs. 10.3 months, p=0.120) and the median progression-free survival (6.5 months vs. 5.8 months, p=0.115). However, there was a significant difference in response rate (62.4% vs. 48.2%, p=0.006). The pre-planned subgroup analyses showed that IP was associated with longer overall survival in male (11.3 months vs. 10.1 months, p=0.036), < 65 years old (12.7 months vs. 11.3 months, p=0.024), and Eastern Cooperative Oncology Group performance status 0/1 (12.4 months vs. 10.9 months, p=0.040) patient groups. The severity of treatment-related adverse events such as grade 3/4 anemia, nausea and diarrhea was more frequent in patients treated with IP.CONCLUSION:
The IP chemotherapy did not significantly improve the survival compared with EP chemotherapy in Korean patients with extensive-disease SCLC.
Texto completo:
Disponible
Contexto en salud:
Enfermedades Desatendidas
Problema de salud:
Diarrea
/
Enfermedades Desatendidas
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Brazo
/
Cisplatino
/
Supervivencia sin Enfermedad
/
Progresión de la Enfermedad
/
Diarrea
/
Quimioterapia
/
Etopósido
/
Carcinoma Pulmonar de Células Pequeñas
/
Anemia
/
Neoplasias Pulmonares
Tipo de estudio:
Ensayo clínico controlado
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Cancer Research and Treatment
Año:
2019
Tipo del documento:
Artículo