US Contrast Enhanced Study as an Imaging Biomarker of Anti-cancer Drug Treatment: Preliminary Study with Paclitaxel and a Xenograft Mouse Tumor Model
Journal of the Korean Society of Medical Ultrasound
; : 147-154, 2011.
Artículo
en Coreano
| WPRIM (Pacífico Occidental)
| ID: wpr-725624
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
We wanted to assess tumor angiogenesis of human prostate cancer cells (PC3) implanted in mice before and after paclitaxel injection via contrast-enhanced ultrasonography (CEUS). MATERIALS ANDMETHODS:
Twelve mice were injected with human prostate cancer cells (PC3) on the back or hind limbs. The mice were grouped into two groups; one was the paclitaxel treated group (n = 6) and the other was the control group, which was treated with normal saline (n = 6). Before injection of paclitaxel into the peritoneal cavity, baseline CEUS was performed by the administration of 500 microl (1x108 microbubbles) of contrast agent. The area under the curve (AUC) up to 50 seconds after contrast injection was derived from the time-intensity curves. After injection of paclitaxel or saline, one week follow up CEUS studies were performed. The changes of the tumor volume and the AUC in both two groups were evaluated. After CEUS, the mice were sacrificed and the microvessel density (MVD) was compared.RESULTS:
In the paclitaxel treated group, the AUC from CEUS showed a significant decrease one week after paclitaxel administration (p = 0.03), even though the tumor volume showed no significant changes (p = 0.116). In the control group, there was no significant decrease of the AUC (p = 0.173). Pathologically, there was a significant difference of microvessel density in both groups (p = 0.002).CONCLUSION:
The AUC from the time intensity curve derived from CEUS showed early change in response to the anti-cancer drug treatment in advance of a tumor size response. The findings of CEUS could be an imaging biomarker for assessing the tumor response to anti-cancer drug treatment.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Cavidad Peritoneal
/
Neoplasias de la Próstata
/
Trasplante Heterólogo
/
Estudios de Seguimiento
/
Paclitaxel
/
Área Bajo la Curva
/
Carga Tumoral
/
Extremidades
/
Microvasos
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Society of Medical Ultrasound
Año:
2011
Tipo del documento:
Artículo