Cilostazol attenuates kainic acid-induced hippocampal cell death
The Korean Journal of Physiology and Pharmacology
; : 63-70, 2018.
Article
en En
| WPRIM
| ID: wpr-727937
Biblioteca responsable:
WPRO
ABSTRACT
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol's effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fosforilación
/
Convulsiones
/
Adenosina Monofosfato
/
Muerte Celular
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Proteína de Unión a Elemento de Respuesta al AMP Cíclico
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Fármacos Neuroprotectores
/
Usos Terapéuticos
/
Hipocampo
/
Ácido Kaínico
/
Neuronas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2018
Tipo del documento:
Article