Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius
Mycobiology
; : 117-120, 2016.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-729443
Biblioteca responsable:
WPRO
ABSTRACT
During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance (¹H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC₅₀ values in the range of 0.7~8.1 µM.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Orthomyxoviridae
/
Protones
/
Espectroscopía de Resonancia Magnética
/
Cromatografía
/
Metanol
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Frutas
/
Hongos
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Neuraminidasa
Idioma:
Inglés
Revista:
Mycobiology
Año:
2016
Tipo del documento:
Artículo