Analysis of relationship between aldosterone level changes and renal function during perioperative period of renal transplantation / 器官移植

ABSTRACT

Objective To investigate the relationship between changes of aldosterone level and renal function during perioperative period of renal transplantation and preliminarily discuss the role of aldosterone in chronic allograft nephropathy.Methods One hundred patients undergoing allogeneic renal transplantation in the Department of Urology of the General Hospital of Shenyang Military from January 1 ,201 0 to December 31 ,201 3 were assigned into the experimental group.According to the Scr levels measured at 30 d after renal transplantation,1 00 patients were divided into groups A (Scr≥1 33 μmol/L,n =1 3)and B (Scr <1 33 μmol/L,n =87).Ten healthy individuals aged 25-35 years were recruited into the control group.In the experimental group,blood sample was collected in the morning upon the day of renal transplantation (0 d),1 ,7,1 5 and 30 d after renal transplantation.In the control group,blood sample was obtained at the same time points for measurement of aldosterone and Scr levels.Results On the day of renal transplantation,the Scr level in the experimental group was (598 ±37)μmol/L,significantly higher compared with (75 ±5)μmol/L in the control group (P <0.05).The aldosterone level in the experimental group was (0.26 ±0.06)ng/dl,considerably higher than (0.1 3 ±0.03) ng/dl in the control group (P <0.05).Compared with 0 d,the Scr levels of group A significantly decreased at postoperative 30 d (P <0.05),whereas no statistical significance was noted in aldosterone levels between two time points (P >0.05).In group B,both Scr and aldosterone levels were significantly decreased at postoperative 30 d (both in P <0.05).Correlation analysis revealed that the serum level of aldosterone was positively correlated with Scr level changes (r =0.85,P <0.05).Conclusions After renal transplantation,change of Scr level is positively correlated with aldosterone level alterations, probably suggesting that aldosterone plays a partial role in mediating injury of transplant kidney during renal transplantation.