Clinical study on treatment of postpartum depression by self-made Yangxue-Shugan decoction combined with psychological intervention / 国际中医中药杂志

ABSTRACT

Objective To observe the clinical effect of Yangxue-Shugan decoction combined with psychological intervention on postpartum depression. Methods 9 A total of 90 patients with postpartum depression were randomly divided into control group and treatment group (45 in each group). The control group was treated with amitriptyline. The treatment group was treated with Yangxue-Shugan decoction and psychological intervention. Both groups were treated for 28 days. Symptoms and signs were scored the symptom classification scale. The degree of depression was evaluated by the Edinburgh postpartum depression scale (EPDS). The Serum estradiol, progesterone, orphanin were measured by radioimmunoassay. The 5-hydroxytryptamine was determined by high performance liquid chromatography. Results The total effective rate was 95.56％ (43/45) in the treatment group and 80.00％ (36/45) in the control group. The difference of the total effective rate between the two groups was statistically significant (Z=-2.462, P=0.014). After treatment, the levels of depression score (0.85 ± 0.63 vs. 1.47 ± 0.58, t=-2.337), flank pain score (0.50 ± 0.31 vs. 0.96 ± 0.43, t=-2.169), loss of appetite score (0.67 ± 0.39 vs. 1.20 ± 0.36,t=-2.774), insomnia with multiple dreams score (0.69 ± 0.43 vs. 1.18 ± 0.56, t=-2.826) in the treatment group were significantly lower than those in the control group (P<0.05). The levels of progesterone (16.20 ± 2.49 ng/ml vs. 27.61 ± 2.97 ng/ml, t=-2.378), orphanin (9.94 ± 2.03 ng/L vs. 15.62 ± 3.38 ng/L, t=-2.137), EPDS score (7.7 ± 2.4 vs. 11.6 ± 4.2, t=-2.449) in the treatment group were significantly lower than those in the control group (P<0.05). While the estradiol (231.93 ± 8.25 pg/ml vs. 197.46 ± 8.72 pg/ml, t=-2.273), 5-hydroxytryptamine (1.90 ± 0.36 μmol/L vs. 1.39 ± 0.27 μmol/L, t=-2.016) in the treatment group were significantly higher than those in the control group (P<0.05). Conclusions The Yangxue-Shugan decoction and psychological intervention in the treatment of postpartum depression can improve the depression status of postpartum depression patients, reduce clinical symptoms and improve clinical efficacy.