The predictor of pathological downgrading after radical prostatectomy in patients with biopsy-proven level 2 of grading groups / 中华泌尿外科杂志
Chinese Journal of Urology
; (12): 25-30, 2019.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-734566
Biblioteca responsable:
WPRO
ABSTRACT
Objective To evaluate the predictors of gleason score pathological downgrading after radical prostatectomy in patients with biopsy-proven level 2 of grading groups (Gleason Score 3 + 4 =7).Methods Data of 252 patients,diagnosed with level 2 of grading groups(Gleason score 3 + 4 =7) prostate cancer by biopsy,with subsequent laparoscopic radical prostatectomy,were retrospectively analyzed.The mean age was 64.3,ranged from 46 to 82 years.The average body mass index (BMI) was 23.2 kg/m2,ranged from 15.2 to 30.4 kg/m2.The median prostate volume,transition zone volume(TZV) and transition zone index(TZI) were 48.9 ml (30.3-73.1 ml),21.4 ml(13.5-31.2 ml) and 0.46% (0.37%-0.58%),respectively.The median value of tPSA,fPSA and PSAD were 1.53 ng/ml(0.67-3.92 ng/ml),9.65 ng/ml (4.13-18.68 ng/ml) and 0.18 ng/(ml · cm3) [0.09-0.50 ng/ (ml · cm3)],respectively.Clinical T stage was also evaluated,including 153 (60.7%) diagnosed as T1e stage,78 (3 1.0%) diagnosed as T2 stage,and 21 (8.3%) diagnosed as T3 stage.There were 58(23.0%) with extracapsular extension,47 (18.7%) patients with seminal vesicle invasion,and 2(0.8%) with lymph node metastasis.Pathological T stage includes 112 (44.4%) diagnosed as T2 stage,55 (21.8%) diagnosed as T3a stage,35 (13.9%) diagnosed as T3b stage,and 50(19.8%) diagnosed as T4 stage.The patients were assigned Prostate ImagingReporting and Data System version 2 scores of 1,2,3,4,and 5 were 45 (17.9%),36 (14.3%),51 (20.2%),68(27.0%)and 52(20.6%),respectively.The patients were categorized into 2 groups with and without pathological downgrading,including downgrade and no downgrade group.Univariate and multivariate logistic regression analysis were done to determine the predictors of pathological downgrading.Results The patients were categorized into downgrade(n =31) and no downgrade group(n =221) of 252 patients.The pathological downgrading was identified in 31 (12.3%).The tPSA,PSAD and PI-RADS scores in patients with downgrade group which were lower than those in without downgrade group (P < 0.05).The logistic regression analysis revealed PI-RADS score was the independent predictor of downgrading(OR =0.364,95% CI 0.253-0.522,P < 0.01).The area under the ROC curve of PI-RADS score was 0.810 and the diagnostic value was the best.Conclusions These findings suggested that PI-RADS scores was predictor for pathological downgrading after radical prostatectomy in patients with biopsy-proven level 2 of grading groups,reduced PI-RADS score (PI-RADS score ≤ 3) is correlated with increased pathological downgrading after radical prostatectomy.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Journal of Urology
Año:
2019
Tipo del documento:
Artículo