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Beta-blockers in the treatment of heart failure / 第二军医大学学报
Artículo en Chino | WPRIM (Pacífico Occidental) | ID: wpr-736833
Biblioteca responsable: WPRO
ABSTRACT
It is now clear that continued stimulation o f the neurohormonal system in heart failure (HF) has serious deleterious effects on the heart. The increase of circulating catecholamines exerts direct toxic ef fect on cardiac myocytes, increases membrane permeability and myocardial fibrosi s; lead to aggravation of HF. β-blockers are commonly used in the treatment of HF including propranolol, metoprolol, bisoprolol, bucindolol and carvedilol. These drugs are used in combination with ACEIs, digitalis and diuretics. Genera lly, the benefits of β-blockade therapy in HF include improving symptoms, decr easing morbidity, mortality, elevating need for hospitalization and quality of l ife. β- blockade therapy arrests and reverts LV remodeling and improves the ri sk of life threatening arrhythmias and sudden cardiac death. A few serious adver se effects include hypotension, heart blocks, bradycardia and fluid retention.
Texto completo: Disponible Base de datos: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Academic Journal of Second Military Medical University Año: 2001 Tipo del documento: Artículo
Texto completo: Disponible Base de datos: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Academic Journal of Second Military Medical University Año: 2001 Tipo del documento: Artículo
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