A case of human infection with highly pathogenic avian influenza A (H7N9) virus through poultry processing without protection measure / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 799-804, 2018.
Article
en Zh
| WPRIM
| ID: wpr-738049
Biblioteca responsable:
WPRO
ABSTRACT
Objective: To investigate the infection pattern and etiological characteristics of a case of human infection with highly pathogenic avian influenza A (H7N9) virus and provide evidence for the prevention and control of human infection with highly pathogenic avian influenza virus. Methods: Epidemiological investigation was conducted to explore the case's exposure history, infection route and disease progression. Samples collected from the patient, environments and poultry were tested by using real time reverse transcriptase-polymerase chain reaction (RT-PCR). Virus isolation, genome sequencing and phylogenetic analysis were conducted for positive samples. Results: The case had no live poultry contact history, but had a history of pulled chicken processing without taking protection measure in an unventilated kitchen before the onset. Samples collected from the patient's lower respiratory tract, the remaining frozen chicken meat and the live poultry market were all influenza A (H7N9) virus positive. The isolated viruses from these positive samples were highly homogenous. An insertion which lead to the addition of multiple basic amino acid residues (PEVPKRKRTAR/GL) was found at the HA cleavage site, suggesting that this virus might be highly pathogenic. Conclusions: Live poultry processing without protection measure is an important infection mode of "poultry to human" transmission of avian influenza viruses. Due to the limitation of protection measures in live poultry markets in Guangzhou, it is necessary to promote the standardized large scale poultry farming, the complete restriction of live poultry sales and centralized poultry slaughtering as well as ice fresh sale.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Filogenia
/
Aves de Corral
/
Zoonosis
/
Pollos
/
China
/
Comercio
/
Gripe Humana
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Reacción en Cadena en Tiempo Real de la Polimerasa
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Subtipo H7N9 del Virus de la Influenza A
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Gripe Aviar
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Epidemiology
Año:
2018
Tipo del documento:
Article