Improvement of Cell Cycle Lifespan and Genetic Damage Susceptibility of Human Mesenchymal Stem Cells by Hypoxic Priming
International Journal of Stem Cells
; : 61-67, 2018.
Article
en En
| WPRIM
| ID: wpr-739921
Biblioteca responsable:
WPRO
ABSTRACT
Hypoxic culture is widely recognized as a method to efficiently expand human mesenchymal stem cells (MSCs) without loss of stem cell properties. However, the molecular basis of how hypoxia priming benefits MSC expansion remains unclear. We report that hypoxic priming markedly extends the cell cycle lifespan rather than augmenting the multipotency of MSC differentiation lineage. Hypoxic priming does not affect to chromosome damage but significantly attenuates the susceptibility of chromosome damage. Our results provide important evidence that multipotency of human MSCs by hypoxic priming is determined by cell cycle lifespan.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Células Madre
/
Envejecimiento
/
Ciclo Celular
/
Células Madre Mesenquimatosas
/
Hipoxia
/
Métodos
Límite:
Humans
Idioma:
En
Revista:
International Journal of Stem Cells
Año:
2018
Tipo del documento:
Article