Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
; : 5-2018.
Article
en En
| WPRIM
| ID: wpr-741575
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo. METHODS: Eleven Sprague-Dawley rats were used, and BTX-A (n = 6) or saline (n = 5) was injected at 13 days of age. All injections were given to the right masseter muscle, and the BTX-A dose was 0.5 units. All of the rats were euthanized at 60 days of age. The skulls of the rats were separated and fixed with 10% formalin for micro-computed tomography (micro-CT) analysis. RESULTS: The anthropometric analysis found that the ramus heights and bigonial widths of the BTX-A-injected group were significantly smaller than those of the saline-injected group (P < 0.05), and the mandibular plane angle of the BTX-A-injected group was significantly greater than in the saline-injected group (P < 0.001). In the BTX-A-injected group, the ramus heights II and III and the mandibular plane angles I and II showed significant differences between the injected and non-injected sides (P < 0.05). The BTX-A-injected side of the mandible in the masseter group showed significantly lower mandibular bone growth compared with the non-injected side. CONCLUSION: BTX-A injection into the masseter muscle influences mandibular bone growth.
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Texto completo:
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Base de datos:
WPRIM
Asunto principal:
Cráneo
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Desarrollo Óseo
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Toxinas Botulínicas
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Ratas Sprague-Dawley
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Toxinas Botulínicas Tipo A
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Formaldehído
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Mandíbula
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Músculo Masetero
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Músculos Masticadores
Límite:
Animals
Idioma:
En
Revista:
Maxillofacial Plastic and Reconstructive Surgery
Año:
2018
Tipo del documento:
Article