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Relationship between eosinophils in nasal discharge and responses to treatment of inhaled glucocorticosteroid in patients with persistent allergic rhinitis / 临床耳鼻咽喉头颈外科杂志
Article en Zh | WPRIM | ID: wpr-746773
Biblioteca responsable: WPRO
ABSTRACT
OBJECTIVE@#To evaluate the treatment responses of persistent allergic rhinitis with and without eosinophils (EOS) in nasal discharge to inhaled glucocorticosteroid (CS), and therefore to verify whether low eosinophil level in nasal discharge can predict poor response to treatment with CS.@*METHOD@#Forty-two symptomatic allergic rhinitis patients, who had not received CS therapy in three months preceding the study, were examined before and 2 month, 4 months and 6 months after treatment with CS. At each visit, all patients underwent symptom scoring and physical sign scoring. The level of eosinophil cationic protein (ECP) in the nasal discharge supernatants was measured by radioimmunoassay. The patients were divided into 2 groups according to nasal discharge EOS percentages, an EOS group (EOS > or = 3%) and a non-EOS group (EOS 0.05), but the ECP level did improve (F = 3.78, P < 0.05). The average daily dose of CS was not different between the two groups at any visits.@*CONCLUSION@#In persistent allergic rhinitis with low EOS in nasal discharge, CS therapy for 6 months failed to improve symptoms and physical signs.
Asunto(s)
Texto completo: 1 Base de datos: WPRIM Asunto principal: Patología / Administración por Inhalación / Resultado del Tratamiento / Proteína Catiónica del Eosinófilo / Quimioterapia / Eosinófilos / Rinitis Alérgica / Glucocorticoides / Recuento de Leucocitos / Metabolismo Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: Zh Revista: Lin chuang er bi yan hou ke za zhi Año: 2012 Tipo del documento: Article
Texto completo: 1 Base de datos: WPRIM Asunto principal: Patología / Administración por Inhalación / Resultado del Tratamiento / Proteína Catiónica del Eosinófilo / Quimioterapia / Eosinófilos / Rinitis Alérgica / Glucocorticoides / Recuento de Leucocitos / Metabolismo Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: Zh Revista: Lin chuang er bi yan hou ke za zhi Año: 2012 Tipo del documento: Article