Characteristics of Lung Allocation and Outcomes of Lung Transplant according to the Korean Urgency Status
Yonsei Medical Journal
; : 992-997, 2019.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-762032
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
We investigated the characteristics of lung allocation and outcomes of lung transplant (LTx) according to the Korean urgency status. MATERIALS ANDMETHODS:
LTx registration in the Korean Organ Transplantation Registry (KOTRY) began in 2015. From 2015 to June 2017, 86 patients who received LTx were enrolled in KOTRY. After excluding one patient who received a heart-lung transplant, 85 were included. Subjects were analyzed according to the Korean urgency status.RESULTS:
Except for Status 0, urgency status was classified based on partial pressure of oxygen in arterial blood gas analysis and functional status in 52 patients (93%). The wait time for lung allograft was well-stratified by urgency (Status 0, 46.5±59.2 days; Status 1, 104.4±98.2 days; Status 2 or 3, 132.2±118.4 days, p=0.009). Status 0 was associated with increased operative times and higher intraoperative blood transfusion. Status 0 was associated with prolonged extracorporeal membrane oxygenation use, postoperative bleeding, and longer mechanical ventilation after operation. Survival of Status 0 patients seemed worse than that of non-Status 0 patients, although differences were not significant.CONCLUSION:
The Korean urgency classification for LTx is determined by using very limited parameters and may not be a true reflection of urgency. Status 0 patients seem to have poor outcomes compared to the other urgency status patients, despite having the highest priority for donor lungs. Further multi-center and nationwide studies are needed to revise the lung allocation system to reflect true urgency and provide the best benefit of lung transplantation.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxígeno
/
Presión Parcial
/
Respiración Artificial
/
Donantes de Tejidos
/
Análisis de los Gases de la Sangre
/
Transfusión Sanguínea
/
Oxigenación por Membrana Extracorpórea
/
Trasplante de Órganos
/
Trasplante de Pulmón
/
Clasificación
Tipo de estudio:
Ensayo clínico controlado
Límite:
Humanos
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2019
Tipo del documento:
Artículo