Melatonin inhibits nicotinic acetylcholine receptor functions in bovine chromaffin cells
International Journal of Oral Biology
; : 50-54, 2019.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-764038
Biblioteca responsable:
WPRO
ABSTRACT
Melatonin is a neurotransmitter that modulates various physiological phenomena including regulation and maintenance of the circadian rhythm. Nicotinic acetylcholine receptors (nAChRs) play an important role in oral functions including orofacial muscle contraction, salivary secretion, and tooth development. However, knowledge regarding physiological crosstalk between melatonin and nAChRs is limited. In the present study, the melatonin-mediated modulation of nAChR functions using bovine adrenal chromaffin cells, a representative model for the study of nAChRs, was investigated. Melatonin inhibited the nicotinic agonist dimethylphenylpiperazinium (DMPP) iodide-induced cytosolic free Ca²⁺ concentration ([Ca²⁺](i)) increase and norepinephrine secretion in a concentration-dependent manner. The inhibitory effect of melatonin on the DMPP-induced [Ca²⁺](i) increase was observed when the melatonin treatment was performed simultaneously with DMPP. The results indicate that melatonin inhibits nAChR functions in both peripheral and central nervous systems.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Diente
/
Norepinefrina
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Sistema Nervioso Central
/
Receptores Nicotínicos
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Ritmo Circadiano
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Agonistas Nicotínicos
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Neurotransmisores
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Células Cromafines
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Señalización del Calcio
/
Citosol
Idioma:
Inglés
Revista:
International Journal of Oral Biology
Año:
2019
Tipo del documento:
Artículo