Study on liver protection and hepatotoxicity of saikosaponin a based on zebrafish model / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2662-2666, 2019.
Article
en Zh
| WPRIM
| ID: wpr-773276
Biblioteca responsable:
WPRO
ABSTRACT
Bupleuri Radix has both liver protection and hepatotoxicity. Saponins are the main pharmacodynamic and toxic components of Bupleuri Radix. Based on zebrafish physical model and the model of alcoholic fatty liver( AFL) pathology,the liver toxic and protective effect of saikosaponin a( SSa) were assessed. The results indicated that 1. 77 μmol·L-1 SSa showed protective effect to AFL zebrafish. 5. 30 μmol·L-1 SSa was hepatotoxic to healthy zebrafish,but it showed protective effect to AFL zebrafish. 5. 62 μmol·L-1 SSa was hepatotoxic to healthy and AFL zebrafish. This study is benefit for clinical safety of saikosaponin a.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Ácido Oleanólico
/
Farmacología
/
Saponinas
/
Pez Cebra
/
Quimioterapia
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Toxicidad
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Hígado Graso Alcohólico
/
Enfermedad Hepática Inducida por Sustancias y Drogas
Límite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2019
Tipo del documento:
Article