Advances of Research on Application of Leukemia Xenotransplantation Model--Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1348-1352, 2019.
Article
en Zh
| WPRIM
| ID: wpr-775715
Biblioteca responsable:
WPRO
ABSTRACT
Abstract Tumor xenograft model (PDTX) derived from leukemia patients is an animal model in which the leukemia cells or primary cell lines of patients are transplanted directly into immunodeficient mice.The emergence of nude mice and SCID mice opened early xenotransplantation, then the NSG, NOG mice and the improved model and humanized mice based on there mice significantly improves the success rate of transplantation. The late presented transplantation of leukemia LSC and transplantation of patient-derived and induced pluripotent stem cells obtained based on iPSC technology provide new insight for the anderstanding leukemia genesis and development, and the new type humanized mouse model with normal lymphatic hematopoietic reconstruction provides a new platform of leukemia cell therapy and immunotherapy for leukemia therapy. PDTX is an important platform for the study of the pathogenesis and drug resistance mechanism of leukemia, as well as the development of new drugs and individualized treatment. In this paper, the recent progress in the construction and application of models of immunodeficient mice and their models is reviewed.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Trasplante Heterólogo
/
Leucemia
/
Modelos Animales de Enfermedad
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2019
Tipo del documento:
Article