A new strategy to intervene tumor metabolism: regulatory targets for amino acid metabolism and advances in drug research / 药学学报
Acta Pharmaceutica Sinica
; (12): 407-419, 2019.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-780134
Biblioteca responsable:
WPRO
ABSTRACT
Reprogramming of metabolism is one of the most critical features in tumorigenesis and tumor growth. Many types of cancer show an increased demand for specific amino acids, rely on exogenous supplies, or alter amino acid metabolic pathways, leading to changes in corresponding amino acid levels to meet the need of tumorigenesis. Therefore, if the level of tumor growth-dependent amino acids can be effectively controlled, a new treatment strategy can be developed from the perspective of cell metabolism. At present, remarkable progress has been made in this field. This paper outlines the amino acid metabolic pathways closely related to tumorigenesis and tumor growth, and summarizes the corresponding regulatory mechanisms and active molecules. Finally, the direction of the field is discussed and prospected for future development.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2019
Tipo del documento:
Artículo