Sarcopenia as a Useful Predictor for Long-Term Mortality in Cirrhotic Patients with Ascites
Journal of Korean Medical Science
; : 1253-1259, 2014.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-79644
Biblioteca responsable:
WPRO
ABSTRACT
This study aimed to assess and compare sarcopenia with other prognostic factors for predicting long-term mortality in cirrhotic patients with ascites. Clinical data of 65 among 89 patients with measurement of all parameters were consecutively collected. Sarcopenia was evaluated as right psoas muscle thickness measurement divided by height (PMTH) (mm/m). During a mean follow-up of 20 (range 1-49) months, 19 (29.2%) of 65 patients died. The values of the area under the receiver operating characteristics curve (AUROC) of Child-Pugh score, Model for End-Stage Liver Disease (MELD) score, MELD-Na, and PMTH for predicting 1-yr mortality were 0.777 (95% CI, 0.635-0.883), 0.769 (95% CI, 0.627-0.877), 0.800 (95% CI, 0.661-0.900), and 0.833 (95% CI, 0.699-0.924), whereas hepatic venous pressure gradient was not significant (AUROC, 0.695; 95% CI. 0.547-0.818, P=0.053). The differences between PMTH and other prognostic variables were not significant (all P>0.05). The best cut-off value of PMTH to predict long-term mortality was 14 mm/m. The mortality rates at 1-yr and 2-yr with PMTH>14 mm/m vs. PMTH14 mm/m (HR, 5.398; 95% CI, 2.111-13.800, P<0.001). In conclusion, sarcopenia, evaluated by PMTH, is an independent useful predictor for long-term mortality in cirrhotic patients with ascites.
Texto completo:
Disponible
Contexto en salud:
ODS3 - Salud y Bienestar
/
ODS3 - Meta 3.4 Reducir las muertes prematuras por enfermedades no transmisibles
Problema de salud:
Meta 3.2: Evitar muertes en recién nacidos y niños menores de 5 años
/
Cirrosis
/
Enfermedades del Sistema Digestivo
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Ascitis
/
Índice de Severidad de la Enfermedad
/
Tomografía Computarizada por Rayos X
/
Análisis de Supervivencia
/
Valor Predictivo de las Pruebas
/
Análisis de Regresión
/
Curva ROC
/
Estudios de Seguimiento
/
Área Bajo la Curva
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2014
Tipo del documento:
Artículo