Relationship of serum FSH with bone mineral density, and prevalence of osteoporosis in Chinese women / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate the relationship between serum follicle-stimulating hormone (FSH) level with bone mineral density (BMD), and the risk rate of osteoporosis in Chinese women.@*METHODS@#Serum FSH concentrations of 699 healthy Chinese women aged 20-82 years were measured by radioimmunoassay (RIA). BMD was measured by dual-energy-X-ray absorptiometry (DXA) at the postero-anterior spine, lateral spine, total hip, and ultra-distal forearm.@*RESULTS@#The level of serum FSH started to increase from 40 years old, and then decreased after 60. Serum FSH level was negatively related to BMD at various sites. At the postero-anterior spine, lateral spine, total hip, and ultra-distal forearm, 4 quartiles of average prevalence of osteoporosis (OP) divided by FSH were 0.57%, 0.43%, 27.1%, and 30.9%, respectively. Compared with the 1st and the 2nd quartile, OP case rate and ill risk in the women of the 3rd and the 4th quartile increased notably, especially in the spine.@*CONCLUSION@#The level of serum FSH may be related to bone loss and the occurrence of osteoporosis in Chinese women.