Expression of thioredoxin-2 for monitoring minimal residual disease in acute leukemia / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 383-387, 2013.
Article
en Zh
| WPRIM
| ID: wpr-814870
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the significance of human thioredoxin-2 (TRX-2) in monitoring minimal residual disease (MRD) in acute leukemia (AL).@*METHODS@#We used real-time quantitative PCR to serially quantitize TRX-2 expression levels in the bone marrow of AL patients at diagnosis (n=68), at complete hematologic remission (CHR, n=57) and at relapse (n=25). Another 25 normal donors served as normal controls. The upper limit of the bone marrow at 91 was regarded as the reference. TRX-2 expression level at CHR with 91). TRX-2 level was correlated to the expression level of MRD.@*CONCLUSION@#TRX-2 may be the marker for AL and used in MRD monitoring.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Tiorredoxinas
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Leucemia Mieloide Aguda
/
Estudios de Casos y Controles
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Neoplasia Residual
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Diagnóstico
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Reacción en Cadena en Tiempo Real de la Polimerasa
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Genética
/
Metabolismo
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Año:
2013
Tipo del documento:
Article