Protein-losing enteropathy in children / 中国实用儿科杂志

ABSTRACT

Protein-losing enteropathy,or protein-losing gastroenteropathy,refers to a group of diseases in which serum proteins are excessively lost from the gastrointestinal tract due to various causes. The pathogenesis mainly includes mucosal erosion and exudation,increased permeability and intestinal lymphatic obstruction. Clinical manifestations vary greatly with underlying diseases,and the common manifestations are diarrhea,edema and malnutrition. The main characteristics of laboratory examination are the decrease of serum albumin and globulin. Increase in 24-hour alpha-1 antitryptase clearance rate or lymphonuclide intestinal protein tracing image can be used as an evidence of intestinal protein loss. Treatment includes dietary therapy and treatment for underlying diseases.