Colonic expression of Runx3 protein and TGF-β(1) and their correlation in patients with irritable bowel syndrome
Asian Pacific Journal of Tropical Medicine
; (12): 547-549, 2011.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-820098
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the role of Runx3 protein and TGF-β(1) in the pathogenesis of irritable bowel syndrome (IBS), as well as the correlation of these two proteins.@*METHODS@#Colonic tissue was collected from patients with IBS and normal persons. The colonic expression of Runx3 protein and TGF-β(1) was detected with immunohistochemistry method. Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.@*RESULTS@#Compared with their counterparts, patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β(1) (P>0.05). Interestingly, there was a significant correlation between Runx3 protein and TGF-β(1) in patients with IBS(P<0.05).@*CONCLUSIONS@#The role of Runx3 protein and TGF-β(1) in the pathogenesis of IBS remains to be further studied.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Inmunohistoquímica
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Regulación de la Expresión Génica
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Colon
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Síndrome del Colon Irritable
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Subunidad alfa 3 del Factor de Unión al Sitio Principal
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Factor de Crecimiento Transformador beta1
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Genética
/
Metabolismo
Límite:
Humanos
Idioma:
Inglés
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2011
Tipo del documento:
Artículo