A case of anti-LebH antibody concurrent Leb antigen suppression during pregnancy in a patient with idiopathic thrombocytopenic purpura / 대한수혈학회지

ABSTRACT

We report the first case of anti-LebH antibody concurrent Leb antigen supression during pregnency. A 32-year-old woman was diagnosed as idiopathic thrombocytopenic purpura at the 20th week of gestation. She was administrated intravenous immunoglobulin and transfused packed red cells due to thrombocytopenia and anemia. Before an elective cesarean section at 38th week of gestation, her red cells were typed B, Rh(D) positive and her serum had anti-A and her Lewis phenotype was Le(a-b-). The antibody screeening test was positive and anti-Leb which was identified in the antibody identification test. However, it revealed stronger reaction against O, Le(a-b+) red cells than B, Le(a-b+) red cells and we concluded that it was anti-LebH. About 1 year after delivery, the anti-LebH was detected as low titer (about 14) but Lewis phenotype was converted to original phenotype as Le(a-b+).