The expression and significance of hTERT and P53 in thyroid carcinoma / 西安交通大学学报·英文版
Academic Journal of Xi'
; an Jiaotong University;(4): 127-130, 2010.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-844738
Biblioteca responsable:
WPRO
ABSTRACT
Objective:
To determine the expression of human telomerase reverse transcriptase (hTERT) and P53 in thyroid carcinoma and its relationship with development and prognosis of the carcinoma.Methods:
Totally 90 cases of thyroid specimens (60 thyroid carcinomas, 10 thyroid adenomas, 10 goitres and 10 normal thyroid tissues) were studied by SP immunohistochemical method.Results:
Positive immunoreactivity of hTERT and P53 was higher in thyroid carcinoma (P<0.05). The positive rates of hTERT and P53 were higher in undifferentiated carcinomas, carcinomas with lymph nodes metastasis or at stage III + IV than in well-differentiated carcinomas, carcinomas without lymph nodes metastasis or at stage I + II (P<0.05). The expression of hTERT was significantly related with that of P53 (P<0.05).Conclusion:
Over-expressed hTERT and P53 may be related to the carcinogenesis and progression of thyroid carcinoma and hTERT expression is related to P53 protein. Examination of expression of hTERT and P53 proteins may be helpful to judge the thyroid cancer's behavior and prognosis.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Academic Journal of Xi'an Jiaotong University
Año:
2010
Tipo del documento:
Artículo