Treatment outcome of conservative surgery plus postoperative radiotherapy for extremity soft tissue sarcoma
Radiation Oncology Journal
; : 62-69, 2012.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-8697
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
To evaluate the treatment outcome and prognostic factor of postoperative radiotherapy for extremity soft tissue sarcoma (STS). MATERIALS ANDMETHODS:
Forty three patients with extremity STS were treated with conservative surgery and postoperative radiotherapy from January 1981 to December 2010 at Korea University Medical Center. Median total 60 Gy (range, 50 to 74.4 Gy) of radiation was delivered and 7 patients were treated with chemotherapy.RESULTS:
The median follow-up period was 70 months (range, 5 to 302 months). Twelve patients (27.9%) sustained relapse of their disease. Local recurrence occurred in 3 patients (7.0%) and distant metastases developed in 10 patients (23.3%). The 5-year overall survival (OS) was 69.2% and disease free survival was 67.9%. The 5-year local relapse-free survival was 90.7% and distant relapse-free survival was 73.3%. On univariate analysis, no significant prognostic factors were associated with development of local recurrence. Histologic grade (p = 0.005) and stage (p = 0.02) influenced the development of distant metastases. Histologic grade was unique significant prognostic factor for the OS on univariate and multivariate analysis. Severe acute treatment-related complications, Common Terminology Criteria for Adverse Events (CTCAE) grade 3 or 4, developed in 6 patients (14.0%) and severe late complications in 2 patients (4.7%).CONCLUSION:
Conservative surgery with postoperative radiotherapy achieved a satisfactory rate of local control with acceptable complication rate in extremity STS. Most failures were distant metastases that correlate with tumor grade and stage. The majority of local recurrences developed within the field. Selective dose escalation of radiotherapy or development of effective systemic treatment might be considered.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Recurrencia
/
Sarcoma
/
Análisis Multivariante
/
Estudios de Seguimiento
/
Resultado del Tratamiento
/
Supervivencia sin Enfermedad
/
Centros Médicos Académicos
/
Extremidades
/
Corea (Geográfico)
/
Metástasis de la Neoplasia
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Radiation Oncology Journal
Año:
2012
Tipo del documento:
Artículo