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SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation
Acta Pharmaceutica Sinica B ; (6): 89-99, 2021.
Article en En | WPRIM | ID: wpr-881126
Biblioteca responsable: WPRO
ABSTRACT
Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury, and its prognosis depends on the balance between hepatocyte death and regeneration. Sirtuin 6 (SIRT6) has been reported to protect against oxidative stress-associated DNA damage. But whether SIRT6 regulates APAP-induced hepatotoxicity remains unclear. In this study, the protein expression of nuclear and total SIRT6 was up-regulated in mice liver at 6 and 48 h following APAP treatment, respectively.
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Texto completo: 1 Base de datos: WPRIM Tipo de estudio: Prognostic_studies Idioma: En Revista: Acta Pharmaceutica Sinica B Año: 2021 Tipo del documento: Article
Texto completo: 1 Base de datos: WPRIM Tipo de estudio: Prognostic_studies Idioma: En Revista: Acta Pharmaceutica Sinica B Año: 2021 Tipo del documento: Article