Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases / 中国修复重建外科杂志
Chinese Journal of Reparative and Reconstructive Surgery
; (12): 758-763, 2023.
Article
en Zh
| WPRIM
| ID: wpr-981665
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To review the research progress of mitochondrial dynamics mediated by optic atrophy 1 (OPA1) in skeletal system diseases.@*METHODS@#The literatures about OPA1-mediated mitochondrial dynamics in recent years were reviewed, and the bioactive ingredients and drugs for the treatment of skeletal system diseases were summarized, which provided a new idea for the treatment of osteoarthritis.@*RESULTS@#OPA1 is a key factor involved in mitochondrial dynamics and energetics and in maintaining the stability of the mitochondrial genome. Accumulating evidence indicates that OPA1-mediated mitochondrial dynamics plays an important role in the regulation of skeletal system diseases such as osteoarthritis, osteoporosis, and osteosarcoma.@*CONCLUSION@#OPA1-mediated mitochondrial dynamics provides an important theoretical basis for the prevention and treatment of skeletal system diseases.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Osteoartritis
/
Osteoporosis
/
Dinámicas Mitocondriales
/
GTP Fosfohidrolasas
Límite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Reparative and Reconstructive Surgery
Año:
2023
Tipo del documento:
Article