Research Progress on Abused Drugs Metabolic in vivo / 法医学杂志
Journal of Forensic Medicine
; (6): 290-295, 2016.
Article
en Zh
| WPRIM
| ID: wpr-984850
Biblioteca responsable:
WPRO
ABSTRACT
Under the catalysis of a variety of metabolic enzymes in vivo, such as UDP-glucuronyl transferases, cytochrome P450, carboxylesterase, sulfotransferase, butyrylcholinesterase, catechol-O-methyl transferase and 6-morphine dehydrogenase, the drugs perform glucuronidation, hydrolysis, oxidation, sulfonation and other reactions, then translate into active or inactive metabolites, which are excreted through urination, bile or the other pathways at last. Different drugs own their different metabolic pathways. This paper introduces the studies about the metabolism of drugs in human and animal in recent years, such as morphine-like drugs, amphetamine, ketamine, cannabis and cocaine, and reviews the research progress about the sites of metabolism, metabolic enzymes, metabolites and physiological activity of those drugs metabolic in vivo.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Oxidación-Reducción
/
Sulfotransferasas
/
Drogas Ilícitas
/
Catecol O-Metiltransferasa
/
Colinesterasas
/
Glucuronosiltransferasa
/
Sistema Enzimático del Citocromo P-450
/
Carboxilesterasa
/
Oxidorreductasas de Alcohol
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Año:
2016
Tipo del documento:
Article