Huaiqihuang Granules in Treatment of Chronic Kidney Disease： A Review / 中国实验方剂学杂志

ABSTRACT

Chronic kidney disease is characterized by renal structural damage and dysfunction （for over three months） caused by various factors. In traditional Chinese medicine， chronic kidney disease can be classified as edema， ischuria， consumptive disease， and anuria and vomiting. The pathogenesis of chronic kidney disease is frequently attributed to the deficiency of lung， spleen and kidney， dampness combined with stasis， and accumulation of turbid toxin. Huaiqihuang granules are a Chinese patent medicine composed of Vanderbylia robiniophila， Lycii Fructus， and Polygonati Rhizoma， with diverse pharmacological effects such as improving immunity and protecting kidney function. It is widely used in the treatment of cancer， chronic kidney disease， and respiratory system diseases. The available studies have demonstrated that Huaiqihuang granules can intervene in the progression of chronic kidney disease via various ways， such as protecting glomerular podocytes， inhibiting the proliferation of glomerular mesangial cells， resisting renal interstitial fibrosis， alleviating renal inflammation and oxidative stress， and regulating renal cell apoptosis and the immune system function. The clinical application of Huaiqihuang granules is based on conventional treatment and has achieved remarkable effects in the treatment of children's nephrotic syndrome， diabetic nephropathy， nephritis of Schonlein-Henoch purpura， IgA nephropathy， and chronic renal failure. Scholars have achieved great progress in the research on the mechanism and the clinical application of Huaiqihuang granules in the treatment of chronic kidney disease. However， the detailed summary of the progress in recent years remains to be carried out. Therefore， this paper reviewed the available studies in this field， aiming to provide a reference for the comprehensive and extensive clinical application of Huaiqihuang granules in the treatment of chronic kidney disease.