The genetic diversity of Plasmodium malariae and Plasmodium brasilianum from human, simian and mosquito hosts in Brazil
Acta Tropica
; 124(1): 27-32, Jun, 2012. map, tab, graf
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-SUCENPROD, Sec. Est. Saúde SP
| ID: biblio-1059322
Biblioteca responsável:
BR93.2
Localização: BR93.2
ABSTRACT
Plasmodium malariae is a protozoan parasite that causes malaria in humans and is genetically indistinguish able from Plasmodium brasilianum, a parasite infecting New World monkeys in Central and South America. P. malariae has a wide and patchy global distribution in tropical and subtropical regions, being found in South America, Asia, and Africa. However, little is known regarding the genetics of these parasites and the similarity between them could be because until now there are only a very few genomic sequences available from simian Plasmodium species. This study presents the first molecular epidemiological data for P. malariae and P. brasilianum from Brazil obtained from different hosts and uses them to explore the genetic diversity in relation to geographical origin and hosts. By using microsatellite genotyping, we discovered that of the 14 human samples obtained from areas of the Atlantic forest, 5 different multilocus genotypes were recorded, while in a sample from an infected mosquito from the same region a different haplo type was found. We also analyzed the longitudinal change of circulating plasmodial genetic profile in two untreated non-symptomatic patients during a 12-months interval...
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Malária
/
Doenças Negligenciadas
Base de dados:
Sec. Est. Saúde SP
/
SESSP-SUCENPROD
Assunto principal:
Plasmodium malariae
/
Malária
Limite:
Animais
/
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Acta Tropica
Ano de publicação:
2012
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidade de São Paulo/BR
/
Wildlife Conservation Society/BR