Anatomical and physiologic assessments in patients with small coronary artery disease: final results of the physiologic and anatomical evaluation prior to and after stent implantation in small coronary vessels (PHANTOM) trial
Am. heart j
; 153(2): 296e.1-296e.7, fev 2007. ilus
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1059464
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
Patients with small coronary arteries are at high risk for complications after percutaneous coronary intervention (PCI). The objective of our study was to investigate the correlation between angiography, intravascular ultrasound (IVUS), and fractional flow reserve (FFR) in patients with moderate stenoses in small (b2.8 mm) coronary arteries. Methods and Results Sixty consecutive patients, of 800 scheduled for PCI during the study period, were prospectively enrolled in the study. The FFR was measured after a 2-minute infusion of adenosine. For the preprocedural assessments, 60 patients underwent an FFR measurement, 56 underwent an IVUS, and 60 underwent an angiography; for the postprocedural assessments, 22 patients underwent an FFR measurement, 18 underwent an IVUS, and 22 underwent an angiography. The jeopardy score for the target vessel was calculated. Data were analyzed by an independent core laboratory. Patients with an FFR N0.75 were deferred from PCI. Patients were stratified in 2 groups according to their FFR values (V0.75 vs N0.75) and were followed for 1 year. Significant (FFR V0.75) coronary stenosis was observed in only 35% of the patients. The mean preprocedural FFR values were 0.79 F 0.13 for the overall population, 0.64 F 0.08 for the patients with an FFR V0.75, and 0.87 F 0.06 for the patients with an FFR N0.75. There was no correlation between angiography, IVUS, and FFR. The jeopardy score was inversely correlated with FFR (R = 0.32). Only a third of the patients with optimal stenting defined by IVUS achieved an FFR N0.90. After 1 year, 24% of the patients with an FFR V0.75 required a repeat PCI. There was no occurrence of myocardial infarction or death, and only 2.6% of the patients deferred from PCI required revascularization. Conclusion Anatomical parameters are limited in determining the hemodynamic significance of small coronary disease. Most moderate stenoses in small coronaries could be safely deferred from PCI based on FFR
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Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Doença da Artéria Coronariana
/
Stents
Idioma:
Inglês
Revista:
Am. heart j
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
Institute Dante Pazzanese of Cardiology/BR
/
San Carlos University Hospital/ES
/
University of Florida/US