Antitumor potential induction and freeradicals production in melanoma cells by BoronNeutronCapture Therapy
Appl. radiat. isot
; 69(12): 1748-1751, Dec. 2011.
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IBPROD, Sec. Est. Saúde SP, SESSP-IBACERVO
| ID: biblio-1059758
Biblioteca responsável:
BR78.1
Localização: BR78.1
ABSTRACT
Antiproliferative and oxidative damage effects occurring in Boron Neutron Capture Therapy (BNCT) in normal fibroblasts and melanoma cell lines were analyzed. Melanoma cells and normal fibroblasts were treated with different concentrations of Boronophe- nylalanine and irradiated with thermal neutron flux. The cellular viability and the oxidative stress were determined. BNCT induced free radicals production and proliferative potential inhibition in melanoma cells. Therefore, this therapeutic technique could be considered efficient to inhibit growth of melanoma with minimal effects on normal tissues.
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Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IBACERVO
/
SESSP-IBPROD
Assunto principal:
Células Cultivadas
/
Melanoma
Idioma:
Inglês
Revista:
Appl. radiat. isot
Ano de publicação:
2011
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Butantan/BR