Leptospiral TlyC is an extracellular matrix-binding protein and does not present hemolysin activity
FEBS Letters
; 583(8): 1381-1385, Apr 17,2009.
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IBPROD, Sec. Est. Saúde SP, SESSP-IBACERVO
| ID: biblio-1062804
Biblioteca responsável:
BR78.1
Localização: BR78.1
ABSTRACT
The role of TlyA, TlyB and TlyC proteins in the biology of Leptospira is still uncertain. Although these proteins have been considered as putative hemolysins, we demonstrate that leptospiral recombinant TlyB and TlyC do not possess hemolytic activity. However, further experiments showed that TlyC is a surface-exposed protein that seems to bind to laminin, collagen IV and fibronectin. The expression of both proteins was detected both in vitro and in vivo. Our findings suggest that TlyB and TlyC are not directly involved in hemolysis, and that TlyC may contribute to Leptospira binding to extracellular matrix (ECM) during host infection.
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Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IBACERVO
/
SESSP-IBPROD
Assunto principal:
Leptospira interrogans
/
Leptospirose
Idioma:
Inglês
Revista:
FEBS Letters
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Butantan/BR