Genetic ancestry effects on the distribution of toll-like receptors (TLRs) genepolymorphisms in a population of the Atlantic Forest, São Paulo, Brazil
Human Immunology
; 79(2): 101-108, Fev, 2018. map, tab, graf
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-SUCENPROD, Sec. Est. Saúde SP
| ID: biblio-1063299
Biblioteca responsável:
BR93.2
Localização: BR93.2
ABSTRACT
The innate immune system governed by toll-like receptors (TLRs) provides the first line of defense against pathogens. Surface-localized TLR1 and TLR6 are known to detect parasite components. TLR encoding genes wereshown to display signatures of recent positive selection in Europeans and might be involved in local adaptation at immune-related genes. To verify the influence of Brazilian population admixture on the distribution of polymorphisms in TLRs, we analyzed the genotype frequencies of 24 polymorphisms distributed across five TLRgenes in a Southeastern Brazilian population where autochthonous cases of malaria occur in small foci oftransmission. The estimation of ancestry showed mainly European ancestry (63%) followed by African ancestry(22%). Mean proportions of European ancestry differed significantly between the genotypes of the TLR1 (I602S) gene and in the TLR6 (P249S) gene. The chance of having the G allele in TLR1 gene increases as Europeanancestry increases as well as the chance of having the T allele in the TLR6 gene. The 602S allele is related to ahypo-responsiveness possibly explaining the high prevalence of asymptomatic malaria cases in areas of Southeastern Brazil. Our results underline the necessity to include informative ancestry markers in genetic association studies in order to avoid biased results...
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Malária
Base de dados:
Sec. Est. Saúde SP
/
SESSP-SUCENPROD
Assunto principal:
Polimorfismo Genético
/
Receptores Toll-Like
Tipo de estudo:
Fatores de risco
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Human Immunology
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Federal University of Pará/BR
/
University of São Paulo/BR