The effect of variable dose and release kinetics on neointimal hyperplasia using a novel paclitaxel-eluting stent platform
J. Am. Coll. Cardiol
; 46(2): 253-260, 2005. ilus, tab
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1063731
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
The aim of this study was to evaluate th effect of variable dose and release kinetics of paclitaxel on neointimal hyperplasia.Conventional paclitaxel-eluting stents use a durable polymer coating as vehicle for drug delivery.The Conor stent (Conor Medsystem, Menlo Park, Califórnia) with intra-strut wells and erodable polymer is specifically designed for drug delivery with programmable pharmakocinetics.Two hundred and forty-four patients with single vessel disease received either a bare metal Conor stent(n=53) or one of six different release formulations that varied in dose (10 or 30yg) and elution release kinetics (first order, zero oder), direction (abluminal, luminal), and duration (5, 10, and 30 days)...
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Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Stents
/
Paclitaxel
/
Hiperplasia
Idioma:
Inglês
Revista:
J. Am. Coll. Cardiol
Ano de publicação:
2005
Tipo de documento:
Artigo
Instituição/País de afiliação:
Academish Zienkenhuis/NL
/
Amphia Ziekenhuis/NL
/
Cardialysis/NL
/
Catharina Ziekanhuis/NL
/
Christchurch Hospital/NL
/
Conor Medsystem/US
/
Erasmus Medical Center/NL
/
Herzzentrum Bodensee/CH
/
Hospital Miguel Perez Carrenas/VE
/
Instituto Cardiovascular de Buenos Ayres/AR